Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid.
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The concomitant administration of uricosuric agents and allopurinol has been associated with a decrease in the excretion of oxypurines hypoxanthine and xanthine and an increase in urinary uric acid excretion compared with that observed with allopurinol alone.
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Drugs called xanthine oxidase inhibitors include allopurinol and febuxostat.
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Approximately 20 of ingested allopurinol is excreted in the feces.
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Allopurinol, azathioprine, and colchicine can all be used to treat gouty arthritis.
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Uric acid levels usually begin to fall within 2-3 days of starting treatment and return to their original allopurinol can lower blood cells that help your body fight infections.
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