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Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the AUC of some statinsThe risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4 may be increased with concomitant use of diltiazemWhen possibleuse a non-CYP3A4-metabolized statin together with diltiazemotherwisedose adjustments for both diltiazem and the statin should be considered along with close monitoring for signs and symptoms of any statin related adverse events.

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