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It has been shown that reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis birth defects with ondanstron. is markedly enhanced when their oxidations are inhibited by zyloprim allopurinol and oxipurinol.
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Rashes that develop in reaction to allopurinol treatment can vary from a slight skin irritation to a severe allergic reaction.
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Extensive studies of Glycomet how much high oral doses of allopurinol in mice up to 100 mg kg day, rats up to 200 mg kg day and rabbits up to 150 mg kg day during days 8 to 16 of gestation produced no teratogenic effects.
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Accordingly, maintenance doses of colchicine generally should be given prophylactically when allopurinol is begun.
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therefore, the concomitant administration of 300 to 600 mg of oral allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine.