Oral administration of clonidine hydrochloride to pregnant rabbits during the period of embryo fetal organogenesis at doses of up to 80 mcg kg day approximately 3 times the oral maximum recommended daily dose mrhd of 0.
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pubmed 14757140 wang xm, zhang zj, bains r, mokha ss effect of antisense knock-down of alpha 2a – and alpha 2c -adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat.
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it may interact with medicines such as clonidine, guanethidine, digitalis, rifampin, disopyramide, asthma medications, heart medications, beta blockers, diabetes medicines taken orally, or insulin.
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