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Published studies demonstrated that colchicine was negative for mutagenicity in the bacterial reverse mutation assayHoweverin vitro chromosomal aberration assays demonstrated the formation of micronuclei following colchicine treatmentBecause published studies demonstrated that colchicine induces aneuploidy through the process of mitotic nondisjunction without structural DNA changescolchicine is not considered clastogenicalthough micronuclei are formed.

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Avoid eating grapefruit or drinking grapefruit . juice while taking colchicine capsulesIt can increase your chances of getting serious side effects.

Limitations of useThe safety and . effectiveness of colchicine capsules for acute treatment of gout flares during prophylaxis has not been studied.

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