Moa isoniazid is both tuberculostatic for resting organisms and tuberculocidal for rapidly dividing organisms .
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the doses of the companion drugs were the same in both treatment groups during the initial phase isoniazid 300 mg, pyrazinamide 2000 mg, and ethambutol 1200 mg.
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13 where resistance to isoniazid is high, ethambutol may be added for the last four months as an alternative.
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however, when drug resistance is unlikely, treatment with rifampin and isoniazid for 6 mo supplemented by pyrazinamide in the initial 2 mo is sufficient.
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patients on isoniazid and rifapentine were seen weekly for dot by either a nurse or an outreach worker.
The reason for maintaining the patient usapharmacy. on inh is that inh is so potent in treating tb that it is foolish to omit it until there is microbiological proof that it is ineffective even though isoniazid resistance so commonly occurs with rifampicin resistance .
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