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Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2
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The following additional adverse reactions occurred more frequently in patients who received losartan than placebofrequencies not knownback painurinary tract infectionand flu-like symptoms.
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Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2
COZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophybut there is evidence that this benefit does not apply to Black patientssee Use In Specific Populations and CLINICAL PHARMACOLOGY
Losartan is also not recommended in children . with hepatic impairmentsee also section 4.4
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Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2
COZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophybut there is evidence that this benefit does not apply to Black patientssee Use In Specific Populations and CLINICAL PHARMACOLOGY
Losartan is also not recommended in children . with hepatic impairmentsee also section 4.4
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Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2
COZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophybut there is evidence that this benefit does not apply to Black patientssee Use In Specific Populations and CLINICAL PHARMACOLOGY
Losartan is also not recommended in children . with hepatic impairmentsee also section 4.4
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Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patientsa lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience with losartan in patients with severe hepatic impairmentTherefore losartan must not be administered in patients with severe hepatic impairmentsee sections 4.24.3 and 5.2
COZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophybut there is evidence that this benefit does not apply to Black patientssee Use In Specific Populations and CLINICAL PHARMACOLOGY
Losartan is also not recommended in children . with hepatic impairmentsee also section 4.4
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