Two members of this group, vera- abrupt interruption of propranolol therapy in individu- pamil calan and diltiazem cardiazem , also have als with angina pectoris has been associated with reap- been approved for use in the therapy of certain pearance of angina, acute myocardial infarction, or death supraventricular tachyarrhythmias see chapter 16 .
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6 mg day given in 2 divided doses group 5 182 patients – diltiazem sr 120 – 360 mg day given in 2 divided doses group 2 186 patients – prazosin 4 – 20 mg day given in 2 divided doses group 2 186 patients – placebo there was washout period of 4 – 8 weeks before randomization patients were titrated over a period of 4 – 8 weeks to a dbp 90 mmhg or until they reached the maximum drug dose primary outcome attainment of blood pressure goal during titration dbp 90 mmhg and dbp of 95 mmhg at one year at one year, the following was seen primary outcome diltiazem – 59 , atenolol – 51 , clonidine – 50 , hctz – 46 , captopril – 42 , prazosin – 42 , placebo – 25 average blood pressure reduction at end of titration phase atenolol sbp 11 mmhg, dbp 12 mmhg average blood pressure reduction at end of titration phase placebo sbp 3 mmhg, dbp 5 mmhg the incidence of side effects with atenolol was similar to that of placebo 3 .
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before using this medicine, consult your doctor or pharmacist if you have an allergic hypersensitivity to diltiazem, you are pregnant or breastfeeding, taking dantrolene, a medicine used for severe muscle spasms or severe fever, acute porphyria, you have a very slow heartbeat – less than 50 beats per minute, heart failure and problems with blood flow to your lungs, or any other serious problems with your heart, including an uneven heartbeat unless you have a pacemaker .
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