For patients with partial dpd deficiency such as those with heterozygous mutations in the dpyd gene and where the benefits of xeloda are considered to outweigh the risks taking into account the suitability of an alternative non-fluoropyrimidine chemotherapeutic regimen , these patients must be treated with extreme caution and frequent monitoring with dose adjusment according to toxicity.

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following grade 3 hand-and-foot syndrome, subsequent doses of xeloda should be decreased see dosage and administration .

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sometimes patients have unusual personal circumstances that do not fit normal eligibility guidelines, which means that the applicant must file a formal appeal to get into the xeloda pap program.

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